Here's the guide (the configuration information is in an appendix)
companion blog with screencasts, but to date those have not been very useful.
Most recently I made the following changes:
- OS X 10.4.10 allows one to change mouse pointer size. Maybe that's always been there, but I didn't notice it before.
- I stopped using the ctrl-mouse scroll zoom feature and instead enabled the keyboard zoom. I turned off the dizzying screen motion default behavior, now the screen is fixed and moves only when "pushed" by the pointer at a screen margin. I set maximal magnification to "two" and I changed the keyboard mapping from an obscure modifier key to the + and - keys at the far right of the keyboard (which she doesn't use).