I like Yahoo Desktop Search, but lately on my home machine it's been quite unstable. Probably something Microsoft did with an update.
Instability causes my geek heart to wander, in this case to Google Desktop. The array of Plug-ins is starting to be very impressive. Google Desktop appears to have a community of developers. It's hard to beat those network effects.
Eudora email is prominently absent. Maybe it's time for me to reevaluate Thunderbird.