The Missing Sync for Palm OS - Synchronize Mac OS X and Palm OS
The web site doesn't emphasize this, but you can use Missing Sync for free for a two week evaluation period. I started today -- it looks very good. A breath of fresh air. I was able to remove the festering, parasitic, incompetent mess that's Palm Desktop from my Tiger machine.
On the other hand, there's iCal. Wow. So much hype for something so feeble. No 'categories' for tasks? You must be joking! I thought the Palm data model was feeble, but iCal makes it look pretty darned complex. There's no way this would handle any kind of demanding workplace.
Looks like Entourage and Missing Sync with a PocketPC device are the best PDA solution for the Mac. This may work ok for my wife however.
Missing sync has a good list of supported conduits.